Detalhe da pesquisa
1.
Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
Nature
; 559(7712): 125-129, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29950729
2.
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Proc Natl Acad Sci U S A
; 118(46)2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34750265
3.
Is Structure-Based Drug Design Ready for Selectivity Optimization?
J Chem Inf Model
; 60(12): 6211-6227, 2020 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33119284
4.
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.
Biochemistry
; 57(31): 4675-4689, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004690
5.
The maximal and current accuracy of rigorous protein-ligand binding free energy calculations.
Commun Chem
; 6(1): 222, 2023 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37838760
6.
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Nat Commun
; 10(1): 2691, 2019 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31217428
7.
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization.
Cell Rep
; 29(1): 62-75.e7, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31577956
8.
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations.
Commun Biol
; 1: 70, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30159405
9.
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.
Elife
; 72018 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29465396
10.
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin.
J Clin Invest
; 126(9): 3526-40, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27482884